MiRNA and associated inflammatory changes from baseline to hypoglycemia in type 2 diabetes.

ABSTRACT:

Objective

Hypoglycemia in type 2 diabetes (T2D) increases morbidity and mortality but the underlying physiological response is still not fully understood, though physiological changes are still apparent 24 hours after the event. Small noncoding microRNA (miRNA) have multiple downstream biological effects that may respond rapidly to stress. We hypothesized that hypoglycemia would induce rapid miRNA changes; therefore, this pilot exploratory study was undertaken.

Methods

A pilot prospective, parallel study in T2D (n=23) and controls (n=23). Insulin-induced hypoglycemia (2mmol/l: 36mg/dl) was induced and blood sampling performed at baseline and hypoglycemia. Initial profiling of miRNA was undertaken on pooled samples identified 96 miRNA that were differentially regulated, follo

SUBMITTER: Ramanjaneya M 

PROVIDER: S-EPMC9395634 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature