Promoter Methylation of QKI as a Potential Specific Biomarker for Early Detection of Colorectal Cancer.

ABSTRACT: Early and specific detection of cancer provides an opportunity for appropriate treatment. Although studies have suggested that QKI is a tumor suppressor gene, no studies have evaluated the diagnostic utility of QKI methylation in colorectal cancer (CRC). Here, we evaluated the methylation status of QKI by integrating the methylation data of tissues and cell lines of multiple cancer types. The diagnostic performance of QKI was analyzed in the discovery dataset from the TCGA CRC 450K array (n = 440) and tested in the test sets (n = 845) from the GEO. The methylation level of QKI was further validated in our independent dataset (n = 388) using targeted bisulfite sequencing. All detected CpG sites in the QKI promoter showed CRC-spe

SUBMITTER: Zhang L 

PROVIDER: S-EPMC9395658 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature