Machine-learning-based contrast-enhanced computed tomography radiomic analysis for categorization of ovarian tumors.

ABSTRACT:

Objectives

This study aims to evaluate the diagnostic performance of machine-learning-based contrast-enhanced CT radiomic analysis for categorizing benign and malignant ovarian tumors.

Methods

A total of 1,329 patients with ovarian tumors were randomly divided into a training cohort (N=930) and a validation cohort (N=399). All tumors were resected, and pathological findings were confirmed. Radiomic features were extracted from the portal venous phase images of contrast-enhanced CT. The clinical predictors included age, CA-125, HE-4, ascites, and margin of tumor. Both radiomics model (including selected radiomic features) and mixed model (incorporating selected radiomic features and clinical predictors) were constructed respectively. Six classifiers [k-nearest neighbor (KNN),

SUBMITTER: Li J 

PROVIDER: S-EPMC9395674 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature