Relationship of cardiometabolic risk biomarkers with DXA and pQCT bone health outcomes in young girls.

ABSTRACT:

Background

Excess weight exerts the positive effect of mechanical loading on bone during development whereas obesity-related metabolic dysfunction may have a detrimental impact. In adults, the presence of metabolic syndrome and type 2 diabetes has been associated with compromised bone density, quality, and strength, and an increased incidence of fractures. The few studies that have investigated the role of cardio-metabolic disease risk biomarkers (CMR) on bone strength in children have given conflicting results. The aim of this study was to assess the combined and independent relationships of cardio-metabolic biomarkers with total body and regional bone parameters in young girls.

Methods

In 306, 9-12 year old girls, measures of whole body fat and lean mass, areal bone minera

SUBMITTER: Hetherington-Rauth M 

PROVIDER: S-EPMC9395974 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature