Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early-stage colorectal cancer.

ABSTRACT:

Background

Liver metastasis is the primary cause of lethal colorectal cancer (CRC). The predominant risk of poor patient prognosis in early-stage CRC emerges as metachronous liver metastasis. This necessitates the search for potential biomarkers for this metastasis to assess treatment outcomes and provide targeted therapy.

Methods

The role of hsa_circ_0048122 in predicting liver metastasis in CRC was probed in this work. This retrospective and multi-center investigation entailed exploration and identification stages with 158 and 176 patients. While RT-qPCR was employed to scrutinize hsa_circ_0048122 expression, Kaplan-Meier survival, and multivariate analyses were used to probe its prognostic impact in early-stage CRC and stage IV CRC cases, respectively.

Results

A st

SUBMITTER: Fang Q 

PROVIDER: S-EPMC9396183 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature