The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches.

ABSTRACT:

Background

Colorectal cancer (CRC) with a high prevalence is recognized as the fourth most common cause of cancer-related death globally. Over the past decade, there has been growing interest in the network of tumor cells, stromal cells, immune cells, blood vessel cells, and fibroblasts that comprise the tumor microenvironment (TME) to identify new therapeutic interventions.

Methods

Databases, such as Google Scholar, PubMed, and Scopus, were searched to provide an overview of the recent research progress related to targeting the TME as a novel therapeutic approach.

Results

Tumor microenvironment as a result of the cross talk between these cells may result in either advantages or disadvantages in tumor development and metastasis, affecting the signals and responses fro

SUBMITTER: Zafari N 

PROVIDER: S-EPMC9396196 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature