Estrogen mediates inflammatory role of mast cells in endometriosis pathophysiology.

ABSTRACT: Endometriosis is an estrogen dependent, chronic inflammatory disease characterized by the growth of endometrial lining outside of the uterus. Mast cells have emerged as key players in regulating not only allergic responses but also other mechanisms such as angiogenesis, fibrosis, and pain. The influence of estrogen on mast cell function has also been recognized as a potential factor driving disease pathophysiology in number of allergic and chronic inflammatory conditions. However, precise information is lacking on the cross talk between endocrine and immune factors within the endometriotic lesions and whether that contributes to the involvement of mast cells with disease pathophysiology. In this study, we observed a significant increase in mast cell numbers within endometriotic lesions com

SUBMITTER: McCallion A 

PROVIDER: S-EPMC9396281 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature