Spatial Extent of Amyloid-β Levels and Associations With Tau-PET and Cognition.

ABSTRACT:

Importance

Preventive trials of anti-amyloid agents might preferably recruit persons showing earliest biologically relevant β-amyloid (Aβ) binding on positron emission tomography (PET).

Objective

To investigate the timing at which Aβ-PET binding starts showing associations with other markers of Alzheimer disease.

Design, setting, and participants

This longitudinal multicentric cohort study included 3 independent cohorts: Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer Disease (PREVENT-AD) (data collected from 2012-2020), Alzheimer Disease Neuroimaging Initiative (ADNI) (data collected from 2005-2019), and Harvard Aging Brain Study (HABS) (data collected from 2011-2019). In a 3-tiered categorization of Aβ-PET binding spatial extent, individu

SUBMITTER: Ozlen H 

PROVIDER: S-EPMC9396472 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature