Microglia depletion as a therapeutic strategy: friend or foe in multiple sclerosis models?

ABSTRACT: Multiple sclerosis is a chronic central nervous system demyelinating disease whose onset and progression are driven by a combination of immune dysregulation, genetic predisposition, and environmental factors. The activation of microglia and astrocytes is a key player in multiple sclerosis immunopathology, playing specific roles associated with anatomical location and phase of the disease and controlling demyelination and neurodegeneration. Even though reactive microglia can damage tissue and heighten deleterious effects and neurodegeneration, activated microglia also perform neuroprotective functions such as debris phagocytosis and growth factor secretion. Astrocytes can be activated into pro-inflammatory phenotype A1 through a mechanism mediated by activated neuroinflammatory microglia, w

SUBMITTER: Wies Mancini VSB 

PROVIDER: S-EPMC9396475 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature