The feasibility of ultrasound-assisted endovascular laser thrombolysis in an acute rabbit thrombosis model.

ABSTRACT:

Purpose

This study aimed to test the feasibility of combined ultrasound and laser technique, namely, ultrasound-assisted endovascular laser thrombolysis (USELT), for thrombolysis by conducting in vivo tests in a rabbit thrombosis model.

Materials and methods

An acute thrombus was created in the right jugular vein of rabbit and then was treated with ultrasound only, laser only, and USELT to dissolve the blood clot. A total of 20 rabbits were used. Out of which, the first three rabbits were used to titrate the laser and ultrasound parameters. Then, five rabbits were treated with ultrasound only, five rabbits were treated with laser only, and seven rabbits were treated with USELT. During USELT, 532-nm laser pulses were delivered endovascularly directly to the clot through a fib

SUBMITTER: Singh R 

PROVIDER: S-EPMC9396669 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature