Enhancement of ergothioneine production by discovering and regulating its metabolic pathway in Cordyceps militaris.

ABSTRACT:

Background

Cordyceps militaris is a traditional medicinal fungus contains a variety of functional ingredients and has been developed as an important mushroom food recently. Ergothioneine, one of the antioxidative compounds in C. militaris, is benefits on aging-related diseases and therefore became a novel functional food nutritive fortifier. Currently, the main diet source of ergothioneine is mushroom food. However, the mushroom farming faces the problems such as rather low ingredient yield and spontaneous degeneration associated fruiting body that restricts large scale production of ergothioneine.

Results

In this study, we excavated the ergothioneine synthetases in mushroom and modified the genes in C. militaris to construct a new ergothioneine synthesis pathway. By further

SUBMITTER: Chen BX 

PROVIDER: S-EPMC9396837 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature