Evaluation of anti-malarial potency of new pyrazole-hydrazine coupled to Schiff base derivatives.

ABSTRACT:

Background

The search for pharmacologically effective agents among molecules bearing multiple functionalities is commonly practiced. In continuation of the search for new anti-malarial agents, new pyrazole-hydrazine coupled Schiff-base derivatives previously synthesized were screened for anti-malarial property.

Methods

Here, in vivo prophylactic and curative activities of the compounds were assessed while their binding affinity for falcipain-2, a crucial enzyme in Plasmodium survival, was done using computational techniques.

Results

The two derivatives (BepINH and BepBeH) respectively led to a significant (p < 0.05) reduction in parasitaemia count (0.76 ± 1.11 and 0.79 ± 1.19) at day 3 post-treatment relative to the negative control (16.37 ± 1.25). For the prophylacti

SUBMITTER: Ibezim A 

PROVIDER: S-EPMC9396901 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature