Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations.

ABSTRACT: A fine balance of regulatory (T_reg) and conventional CD4⁺ T cells (T_conv) is required to prevent harmful immune responses, while at the same time ensuring the development of protective immunity against pathogens. As for many cellular processes, sphingolipid metabolism also crucially modulates the T_reg/T_conv balance. However, our understanding of how sphingolipid metabolism is involved in T cell biology is still evolving and a better characterization of the tools at hand is required to advance the field. Therefore, we established a reductionist liposomal membrane model system to imitate the plasma membrane of mouse T_reg and T_conv with regards to their ceramide content. We found that the capacity of membranes to inc

SUBMITTER: Eder S 

PROVIDER: S-EPMC9397063 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature