New Mutations in the 5' Region of the Notch Gene Affect Drosophila melanogaster Oogenesis.

ABSTRACT: The Notch pathway is an important and evolutionarily conserved signaling system involved in the development of multicellular organisms. Notch signaling plays an important role in the regulation of proliferation and differentiation of many cell types. In this study, we report new aspects of Notch gene participation in oogenesis using our previously generated mutations. The mutations consist of an insertion of an auxiliary element of a transgene construct into the first intron of the gene and a series of directed deletions within the 5' regulatory region of Notch. We showed that some of these mutations affect Drosophila oogenesis. This insertion, either alone or in combination with the deletion of an insulator sequence, led to lower expression of Notch in the ovar

SUBMITTER: Volkova EI 

PROVIDER: S-EPMC9397085 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature