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Dominant Negative TRAF3 Variant With Recurrent Mycobacterium abscessus Infection and Bronchiectasis.

ABSTRACT: Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12-interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-α-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies.

SUBMITTER: Liew MF

PROVIDER: S-EPMC9397382 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Dominant Negative TRAF3 Variant With Recurrent Mycobacterium abscessus Infection and Bronchiectasis.

Liew Mei Fong MF Lim Hui Fang HF Liang Mui Cheng MC Lim Ives I Tan Zhaohong Z Tan Rachel Ying Min RYM Sam Qi Hui QH Soe Win Mar WM Tay Sen Hee SH Xu Shengli S Chang Matthew Wook MW Foo Roger R Soong Tuck Wah TW Ravikumar Sharada S Chai Louis Yi Ann LYA

Open forum infectious diseases 20220803 8

Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12-interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-α-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies. ...[more]

PMID: 36004314

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