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Facile preparation of poly(N-isopropylacrylamide)/graphene oxide nanocomposites for chemo-photothermal therapy.


ABSTRACT: Carbon-based nanomaterials, such as carbon nanotubes, fullerenes, nanodiamonds, and graphene, have been investigated for various biomedical applications, including biological imaging, photothermal therapy, drug/gene delivery, cancer therapy, biosensors, and electrochemical sensors. Graphene oxide (GO) has unique physicochemical properties and can be used to restore conductivity through oxidation. In this study, we developed poly(N-isopropylacrylamide) (PNIPAM)-based nanogel systems containing GO for controlled in vitro drug delivery. The photothermal effects of the PNIPAM/GO- and PNIPAMAAM/GO-based nanogel systems were enhanced. The release of DOX from the PNIPAM/GO-based nanogel was achieved using the photothermal effect of near-infrared irradiation. Using a Cell Counting Kit-8 assay, the cytotoxicity of all conditions demonstrated that the PNIPAM composite-based nanogels were biocompatible with no significance.

SUBMITTER: Baipaywad P 

PROVIDER: S-EPMC9397426 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Facile preparation of poly(<i>N</i>-isopropylacrylamide)/graphene oxide nanocomposites for chemo-photothermal therapy.

Baipaywad Phornsawat P   Ryu Naeun N   Im Soo-Seok SS   Lee Ukjae U   Son Hyung Bin HB   Kim Won Jong WJ   Park Hansoo H  

Designed monomers and polymers 20220815 1


Carbon-based nanomaterials, such as carbon nanotubes, fullerenes, nanodiamonds, and graphene, have been investigated for various biomedical applications, including biological imaging, photothermal therapy, drug/gene delivery, cancer therapy, biosensors, and electrochemical sensors. Graphene oxide (GO) has unique physicochemical properties and can be used to restore conductivity through oxidation. In this study, we developed poly(<i>N</i>-isopropylacrylamide) (PNIPAM)-based nanogel systems contai  ...[more]

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