ScRNA-seq reveals ATPIF1 activity in control of T cell antitumor activity.

ABSTRACT: ATP synthase inhibitory factor 1 (ATPIF1) is a mitochondrial protein with an activity in inhibition of F₁F_o-ATP synthase. ATPIF1 activity remains unknown in the control of immune activity of T cells. In this study, we identified ATPIF1 activity in the induction of CD8⁺ T cell function in tumor models through genetic approaches. ATPIF1 gene inactivation impaired the immune activities of CD8⁺ T cells leading to quick tumor growth (B16 melanoma and Lewis lung cancer) in ATPIF1-KO mice. The KO T cells exhibited a reduced activity in proliferation and IFN-γ secretion with metabolic reprogramming of increased glycolysis and decreased oxidative phosphorylation (OXPHOS) after activation. T cell exhaustion was increased in the tumor infiltrating leukocyte

SUBMITTER: Zhong G 

PROVIDER: S-EPMC9397437 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature