Electrical stimulated GLUT4 signalling attenuates critical illness-associated muscle wasting.

ABSTRACT:

Background

Critical illness myopathy (CIM) is a debilitating condition characterized by the preferential loss of the motor protein myosin. CIM is a by-product of critical care, attributed to impaired recovery, long-term complications, and mortality. CIM pathophysiology is complex, heterogeneous and remains incompletely understood; however, loss of mechanical stimuli contributes to critical illness-associated muscle atrophy and weakness. Passive mechanical loading and electrical stimulation (ES) therapies augment muscle mass and function. While having beneficial outcomes, the mechanistic underpinning of these therapies is less known. Therefore, here we aimed to assess the mechanism by which chronic supramaximal ES ameliorates CIM in a unique experimental rat model of critical care.<

SUBMITTER: Addinsall AB 

PROVIDER: S-EPMC9397497 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature