Safety and Stability of Antibody-Dye Conjugate in Optical Molecular Imaging.

ABSTRACT:

Purpose

The development of molecularly targeted tracers is likely to improve the accuracy of diagnostic, screening, and therapeutic tools. Despite the many therapeutic antibodies that are FDA-approved with known toxicity, only a limited number of antibody-dye conjugates have been introduced to the clinic. Thorough evaluation of the safety, stability, and pharmacokinetics of antibody conjugates in the clinical setting compared with their parental components could accelerate the clinical approval of antibodies as agents for molecular imaging. Here we investigate the safety and stability of a near-infrared fluorescent dye (IRDye800CW) conjugated panitumumab, an approved therapeutic antibody, and report on the product stability, pharmacokinetics, adverse events, and QTc interval change

SUBMITTER: Pei J 

PROVIDER: S-EPMC9398032 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature