Diffuse alveolar damage patterns reflect the immunological and molecular heterogeneity in fatal COVID-19.

ABSTRACT:

Background

Severe COVID-19 lung disease exhibits a high degree of spatial and temporal heterogeneity, with different histological features coexisting within a single individual. It is important to capture the disease complexity to support patient management and treatment strategies. We provide spatially decoded analyses on the immunopathology of diffuse alveolar damage (DAD) patterns and factors that modulate immune and structural changes in fatal COVID-19.

Methods

We spatially quantified the immune and structural cells in exudative, intermediate, and advanced DAD through multiplex immunohistochemistry in autopsy lung tissue of 18 COVID-19 patients. Cytokine profiling, viral, bacteria, and fungi detection, and transcriptome analyses were performed.

Findings

Spatial DA

SUBMITTER: Erjefalt JS 

PROVIDER: S-EPMC9398470 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature