Metal-based anticancer agents as immunogenic cell death inducers: the past, present, and future.

ABSTRACT: Cancer is the deadliest disease in the world behind heart disease. Sadly, this remains true even as we suffer the ravages of the Covid-19 pandemic. Whilst current chemo- and radiotherapeutic treatment strategies have significantly improved the patient survival rate, disease reoccurrence continues to pose a deadly risk for all too many patients. Incomplete removal of tumour cells from the body increases the chances of metastasis and developing resistance against current treatments. Immunotherapy represents a therapeutic modality that has helped to overcome these limitations in recent decades. However, further progress is needed. So-called immunogenic cell death (ICD) is a recently discovered and unique mode of cell death that could trigger this necessary further progress. ICD involves stimu

SUBMITTER: Sen S 

PROVIDER: S-EPMC9398513 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature