Donor Macrophages Modulate Rejection After Heart Transplantation.

ABSTRACT:

Background

Cellular rejection after heart transplantation imparts significant morbidity and mortality. Current immunosuppressive strategies are imperfect, target recipient T cells, and have adverse effects. The innate immune response plays an essential role in the recruitment and activation of T cells. Targeting the donor innate immune response would represent the earliest interventional opportunity within the immune response cascade. There is limited knowledge about donor immune cell types and functions in the setting of cardiac transplantation, and no current therapeutics exist for targeting these cell populations.

Methods

Using genetic lineage tracing, cell ablation, and conditional gene deletion, we examined donor mononuclear phagocyte diversity and macrophage function d

SUBMITTER: Kopecky BJ 

PROVIDER: S-EPMC9398940 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature