Poor early childhood growth is associated with impaired lung function: Evidence from a Ghanaian pregnancy cohort.

ABSTRACT:

Objectives

Nearly 40% of African children under 5 are stunted. We leveraged the Ghana randomized air pollution and health study (GRAPHS) cohort to examine whether poorer growth was associated with worse childhood lung function.

Study design

GRAPHS measured infant weight and length at birth and 3, 6, 9,12 months, and 4 years of age. At age 4 years, n = 567 children performed impulse oscillometry. We employed multivariable linear regression to estimate associations between birth and age 4 years anthropometry and lung function. Next, we employed latent class growth analysis (LCGA) to generate growth trajectories through age 4 years. We employed linear regression to examine associations between growth trajectory assignment and lung function.

Results

Birth weight and age 4

SUBMITTER: Kaali S 

PROVIDER: S-EPMC9398957 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature