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Structural advances in transcription elongation.

ABSTRACT: Transcription is the first step of gene expression and involves RNA polymerases. After transcription initiation, RNA polymerase enters elongation followed by transcription termination at the end of the gene. Only recently, structures of transcription elongation complexes bound to key transcription elongation factors have been determined in bacterial and eukaryotic systems. These structures have revealed numerous insights including the basis for transcriptional pausing, RNA polymerase interaction with large complexes such as the ribosome and the spliceosome, and the transition into productive elongation. Here, we review these structures and describe areas for future research.

SUBMITTER: Mohamed AA

PROVIDER: S-EPMC9398977 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Structural advances in transcription elongation.

Mohamed Abdallah A AA Vazquez Nunez Roberto R Vos Seychelle M SM

Current opinion in structural biology 20220709

Transcription is the first step of gene expression and involves RNA polymerases. After transcription initiation, RNA polymerase enters elongation followed by transcription termination at the end of the gene. Only recently, structures of transcription elongation complexes bound to key transcription elongation factors have been determined in bacterial and eukaryotic systems. These structures have revealed numerous insights including the basis for transcriptional pausing, RNA polymerase interaction ...[more]

PMID: 35816930

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