P38 MAPK Is a Major Regulator of Amyloid Beta-Induced IL-6 Expression in Human Microglia.

ABSTRACT: The accumulation of amyloid beta (Aβ) plaques in the brain is a hallmark of Alzheimer's disease (AD) pathology. Microglial activation-mediated neuroinflammation has been implicated in the pathogenesis of AD and the expression levels of interleukin-6 (IL-6) were increased in the brains of AD patients. However, the mechanisms by which IL-6 expression is regulated in human microglia are incompletely understood. Here, we show that Aβ_1-40 oligomers (Aβ₄₀) dose-dependently stimulate IL-6 expression in HMC3 human microglial cells. Treatment with Aβ₄₀ promotes the transcription of IL-6 and tumor necrosis factor α (TNFα) mRNAs in both HMC3 and THP-1 cells. Mechanistic studies reveal that Aβ₄₀-induced increase of IL-6 secretion is associated with the activ

SUBMITTER: Lin H 

PROVIDER: S-EPMC9398979 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature