Estimated GFR Slope Across CKD Stages in Primary Hyperoxaluria Type 1.

ABSTRACT:

Rationale & objective

Primary hyperoxaluria type 1 (PH1) is an autosomal recessive disorder of glyoxylate metabolism that results in early-onset kidney stone disease, nephrocalcinosis, and kidney failure. There is an unmet need for reliable markers of disease progression to test effectiveness of new treatments for patients with PH. In this study, we assessed the rate of estimated glomerular filtration rate (eGFR) decline across chronic kidney disease (CKD) glomerular filtration rate (GFR) categories (CKD G2-G5) in a cohort of patients with PH1.

Study design

Retrospective observational study.

Setting & participants

Patients with PH1 enrolled in the Rare Kidney Stone Consortium (RKSC) registry who did not have kidney failure at diagnosis and who had at least 2 eGFR valu

SUBMITTER: Singh P 

PROVIDER: S-EPMC9398980 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature