Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI.

ABSTRACT:

Purpose

Recently, a significant association was shown between novel growth patterns on histopathology of prostate cancer (PCa) and prostate-specific membrane antigen (PSMA) uptake on [⁶⁸Ga]PSMA-PET. It is the aim of this study to evaluate the association between these growth patterns and ADC (mm²/1000 s) values in comparison to [⁶⁸Ga]PSMA uptake on PET/MRI.

Methods

We retrospectively evaluated patients who underwent [⁶⁸Ga]PSMA PET/MRI for staging or biopsy guidance, followed by radical prostatectomy at our institution between 07/2016 and 01/2020. The dominant lesion per patient was selected based on histopathology and correlated to PET/MRI in a multidisciplinary meeting, and quantified using SUV_max for PSMA uptake and AD

SUBMITTER: Laudicella R 

PROVIDER: S-EPMC9399036 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature