Assessment of malignancy and PSMA expression of uncertain bone foci in [¹⁸F]PSMA-1007 PET/CT for prostate cancer-a single-centre experience of PET-guided biopsies.

ABSTRACT:

Purpose

Uncertain focal bone uptake (UBU) with intensive radiopharmaceutical avidity are frequently observed in patients undergoing [¹⁸F]PSMA-1007 PET/CT for the detection of prostate cancer (PC). Such foci can pose diagnostic conundrums and risk incorrect staging. The aim of this short communication is to share the results of PET-guided biopsies of such foci.

Methods

A retrospective analysis revealed 10 patients who were referred to our department for PET-guided biopsy of UBU visible in a previous [¹⁸F]PSMA-1007 PET/CT. [¹⁸F]-PSMA-1007 PET-guided biopsy was conducted for 11 PSMA-avid bone foci in these 10 patients. The biopsy materials were analysed for tissue typing, and immunohistochemistry (IHC) was performed for prostate-specific-membran

SUBMITTER: Vollnberg B 

PROVIDER: S-EPMC9399054 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature