Fibrin-targeting molecular MRI in inflammatory CNS disorders.

ABSTRACT:

Background

Fibrin deposition is a fundamental pathophysiological event in the inflammatory component of various CNS disorders, such as multiple sclerosis (MS) and Alzheimer's disease. Beyond its traditional role in coagulation, fibrin elicits immunoinflammatory changes with oxidative stress response and activation of CNS-resident/peripheral immune cells contributing to CNS injury.

Purpose

To investigate if CNS fibrin deposition can be determined using molecular MRI, and to assess its capacity as a non-invasive imaging biomarker that corresponds to inflammatory response and barrier impairment.

Materials and methods

Specificity and efficacy of a peptide-conjugated Gd-based molecular MRI probe (EP2104-R) to visualise and quantify CNS fibrin deposition were evaluated. Pro

SUBMITTER: Lohmeier J 

PROVIDER: S-EPMC9399196 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature