Imaging joint infections using D-methyl-¹¹C-methionine PET/MRI: initial experience in humans.

ABSTRACT:

Purpose

Non-invasive imaging is a key clinical tool for detection and treatment monitoring of infections. Existing clinical imaging techniques are frequently unable to distinguish infection from tumors or sterile inflammation. This challenge is well-illustrated by prosthetic joint infections that often complicate joint replacements. D-methyl-¹¹C-methionine (D-¹¹C-Met) is a new bacteria-specific PET radiotracer, based on an amino acid D-enantiomer, that is rapidly incorporated into the bacterial cell wall. In this manuscript, we describe the biodistribution, radiation dosimetry, and initial human experience using D-¹¹C-Met in patients with suspected prosthetic joint infections.

Methods

614.5 ± 100.2 MBq of D-¹¹C-Met was synthesized

SUBMITTER: Polvoy I 

PROVIDER: S-EPMC9399217 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature