Association of early hyponatremia and the development of acute kidney injury in critically ill children.

ABSTRACT:

Background

Hyponatremia is an independent prognostic factor for mortality; however, the reason for this remains unclear. An observed relationship between hyponatremia and the development of acute kidney injury (AKI) has been reported in certain disease states, but hyponatremia has not been evaluated as a predictor of AKI in critically ill patients or children.

Methods

This is a single-center retrospective cohort study of critically ill children admitted to a tertiary care center. We performed regression analysis to assess the association between hyponatremia at ICU admission and the development of new or worsening stage 2 or 3 (severe) AKI on days 2-3 following ICU admission.

Results

Among the 5057 children included in the study, early hyponatremia was present in 13.3

SUBMITTER: Formeck CL 

PROVIDER: S-EPMC9399308 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature