Effect of cognitive reserve on amnestic mild cognitive impairment due to Alzheimer's disease defined by fluorodeoxyglucose-positron emission tomography.

ABSTRACT: This study aimed to investigate the effect of cognitive reserve (CR) on the rate of cognitive decline and cerebral glucose metabolism in amnestic mild cognitive impairment (MCI) using the Study on Diagnosis of Early Alzheimer's Disease-Japan (SEAD-J) dataset. The patients in SEAD-J underwent cognitive tests and fluorodeoxyglucose-positron emission tomography (FDG-PET). MCI to be studied was classified as amnestic MCI due to Alzheimer's disease (AD) with neurodegeneration. A total of 57 patients were visually interpreted as having an AD pattern (P1 pattern, Silverman's classification). The 57 individuals showing the P1 pattern were divided into a high-education group (years of school education ≥13, N = 18) and a low-education group (years of school education ≤12, N = 39). Voxe

SUBMITTER: Kato T 

PROVIDER: S-EPMC9399434 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature