CCL5 mediates breast cancer metastasis and prognosis through CCR5/Treg cells.

ABSTRACT:

Background and aims

CCL5 is considered to contribute to the biological function of a variety of cancer types, but its specific mechanism is still unclear. This study aimed to reveal the mechanism of CCL5 in the invasion, metastasis, and prognosis of breast cancer.

Methods

The expression of CCL5 in tumor tissue and serum was measured with a Luminex protein detection kit, and the correlation between CCL5 and clinical parameters was evaluated. Kaplan-Meier analysis was used to analyze the effect of CCL5 on the prognosis of breast cancer patients. Protein interaction network analysis and gene coexpression were used to determine the receptor that has the strongest interaction with CCL5. Enrichment analysis was used to study the possible pathway by which CCL5 affects breast cancer

SUBMITTER: Qiu J 

PROVIDER: S-EPMC9399502 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature