A glucokinase-linked sensor in the taste system contributes to glucose appetite.

ABSTRACT:

Objectives

Dietary glucose is a robust elicitor of central reward responses and ingestion, but the key peripheral sensors triggering these orexigenic mechanisms are not entirely known. The objective of this study was to determine whether glucokinase, a phosphorylating enzyme with known glucosensory roles, is also expressed in taste bud cells and contributes to the immediate hedonic appeal of glucose-containing substances.

Methods and results

Glucokinase (GCK) gene transcripts were localized in murine taste bud cells with RNAScope®, and GCK mRNA was found to be upregulated in the circumvallate taste papillae in response to fasting and after a period of dietary access to added simple sugars in mice, as determined with real time-qPCR. Pharmacological activation of glucokinase w

SUBMITTER: Chometton S 

PROVIDER: S-EPMC9399534 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature