COQ8B glomerular nephropathy: Outcomes after kidney transplantation and analysis of characteristics in Chinese population

ABSTRACT:

Background

Mutation in the COQ8B gene can cause COQ8B glomerular nephropathy (COQ8B-GN), which is rare and associated with steroid-resistant nephrotic syndrome (SRNS) as well as rapid progression to end-stage renal disease (ESRD). The aim of this study was to analyze the prognosis and recurrence risk of COQ8B-GN in patients after kidney transplantation (KTx) and summarize the characteristics of the Chinese population.

Methods

A retrospective study included four cases treated in our hospital with a diagnosis of COQ8B-GN. Chinese and foreign studies were searched from database inception to February 2022.

Results

A total of four cases were included, with the age of onset ranging from 4 to 9 years. The initial presentations were SRNS and asymptomatic proteinuria. Onl

SUBMITTER: Zeng S 

PROVIDER: S-EPMC9399612 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature