Benefit-to-harm ratio and cost-effectiveness of government-recommended gastric cancer screening in China: A modeling study

ABSTRACT:

Objective

Current guidelines recommend the gastric cancer risk score scale (GCRSS) for screening in gastric cancer (GC) high-risk populations in China. This study aimed to estimate the clinical benefits, harms, cost, and cost-effectiveness of the GCRSS screening strategy from a Chinese healthcare system perspective.

Materials and methods

Using a microsimulation model, we evaluated 7 screening scenarios of the GCRSS with varying starting ages. We simulated 100,000 individuals from the age of 20 for each screening scenario. The main outcomes included GC incidence reduction, number of cause-specific deaths, costs, quality-adjusted life year (QALY), incremental cost-effectiveness ratio (ICER), and benefit-to-harm ratio. Deterministic and probabilistic sensitivity analyses wer

SUBMITTER: Qin S 

PROVIDER: S-EPMC9399635 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature