M6A regulator-based methylation modification patterns and characterization of tumor microenvironment in acute myeloid leukemia.

ABSTRACT: RNA N6-methyladenosine (m6A) is the most common and intensively studied RNA modification that critically regulates RNA metabolism, cell signaling, cell survival, and differentiation. However, the overall role of multiple m6A regulators in the tumor microenvironment (TME) has not yet been fully elucidated in acute myeloid leukemia (AML). In our study, we explored the genetic and transcriptional alterations of 23 m6A regulators in AML patients. Three distinct molecular subtypes were identified and associated with prognosis, patient clinicopathological features, as well as TME characteristics. The TME characterization revealed that m6A patterns were highly connected with metabolic pathways such as biosynthesis of unsaturated fatty acids, cysteine and methionine metabolism, and citrate cycle T

SUBMITTER: Xu ZJ 

PROVIDER: S-EPMC9399688 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature