Pharmacokinetics and bioequivalence of two cyclosporine oral solution formulations in cats.

ABSTRACT: The pharmacokinetic profiles and bioequivalence of two cyclosporine oral solutions were investigated in cats. Twenty-four cats were randomly allocated to two equally sized treatment groups in a randomized four-cycle, and dual-sequence cross-over design. Test and reference articles were orally administered in a single dose of 7 mg/kg Bodyweight. Serial blood samples were collected, and blood cyclosporine concentration was determined by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). No significant differences were present in the major pharmacokinetic parameters (C_max, AUC_0-last,) between the two formulations. The blood profiles of cyclosporine following the administration of both formulations were similar. The findings of the study suggested tha

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9399922 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature