Effects of different types of non-cardiac surgical trauma on hippocampus-dependent memory and neuroinflammation.

ABSTRACT:

Background

Older individuals have been reported to suffer from cognitive disorders after surgery. Various types of surgical trauma have been used to establish postoperative cognitive dysfunction (POCD) animal models in preclinical studies. However, few comparative analyses of these animal models were conducted.

Methods

Tibial surgery, abdominal surgery, and extended abdominal surgery were performed on aged ICR mice to establish POCD models. Behavioral tests included open field, novel object recognition, fear conditioning, and Morris water maze tests. The Z-score methodology was adopted to obtain a comprehensive and integrated memory performance profile. The changes in hippocampal neuroinflammation were analyzed by ELISA, PCR, and immunofluorescence.

Results

In this st

SUBMITTER: Lu B 

PROVIDER: S-EPMC9399929 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature