Implications of NKG2A in immunity and immune-mediated diseases.

ABSTRACT: In recent studies, NKG2A is revealed to be a key immune checkpoint for both natural killer (NK) cells and CD8⁺ T cells. It form heterodimer receptors with CD94, and targets the peptide-presenting human leukocyte antigen-E (HLA-E) molecules. Upon crosslinking, NKG2A/CD94 delivers inhibitory signals for NK cells and CD8⁺ T cells, while blocking NKG2A can effectively unleash functions of these cytotoxic lymphocytes. The interaction between NKG2A and HLA-E contributes to tumor immune escape, and NKG2A-mediated mechanisms are currently being exploited to develop potential antitumor therapeutic strategies. In addition, growing evidence shows that NKG2A also plays important roles in other immune-related diseases including viral infections, autoimmune diseases, inflammatory d

SUBMITTER: Wang X 

PROVIDER: S-EPMC9399941 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature