Persistent but atypical germinal center reaction among 3^rd SARS-CoV-2 vaccination after rituximab exposure.

ABSTRACT:

Background

Durable vaccine-mediated immunity relies on the generation of long-lived plasma cells and memory B cells (MBCs), differentiating upon germinal center (GC) reactions. SARS-CoV-2 mRNA vaccination induces a strong GC response in healthy volunteers (HC), but limited data is available about response longevity upon rituximab treatment.

Methods

We evaluated humoral and cellular responses upon 3rd vaccination in seven patients with rheumatoid arthritis (RA) who initially mounted anti-spike SARS-CoV-2 IgG antibodies after primary 2x vaccination and got re-exposed to rituximab (RTX) 1-2 months after the second vaccination. Ten patients with RA on other therapies and ten HC represented the control groups. As control for known long-lived induced immunity, we analyzed humoral

SUBMITTER: Stefanski AL 

PROVIDER: S-EPMC9399943 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature