Mouse Digit Tip Regeneration Is Mechanical Load Dependent.

ABSTRACT: Amputation of the mouse digit tip results in blastema-mediated regeneration. In this model, new bone regenerates de novo to lengthen the amputated stump bone, resulting in a functional replacement of the terminal phalangeal element along with associated non-skeletal tissues. Physiological examples of bone repair, such as distraction osteogenesis and fracture repair, are well known to require mechanical loading. However, the role of mechanical loading during mammalian digit tip regeneration is unknown. In this study, we demonstrate that reducing mechanical loading inhibits blastema formation by attenuating bone resorption and wound closure, resulting in the complete inhibition of digit regeneration. Mechanical unloading effects on wound healing and regeneration are completely reversible whe

SUBMITTER: Dolan CP 

PROVIDER: S-EPMC9400037 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature