An allostatic epigenetic memory on chromatin footprints after double-hit acute stress.

ABSTRACT: Stress induces allostatic responses, whose limits depend on genetic background and the nature of the challenges. Allostatic load reflects the cumulation of these reponses over the course of life. Acute stress is usually associated with adaptive responses, although, depending on the intensity of the stress and individual differences , some may experience maladaptive coping that persists through life and may influence subsequent responses to stressful events, as is the case of post-traumatic stress disorder. We investigated the behavioral traits and epigenetic signatures in a double-hit mouse model of acute stress in which heterotypic stressors (acute swim stress and acute restraint stress) were applied within a 7-day interval period. The ventral hippocampus was isolated to study the footpri

SUBMITTER: Caradonna SG 

PROVIDER: S-EPMC9400173 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature