Faecal microbiota transplant ameliorates gut dysbiosis and cognitive deficits in Huntington's disease mice.

ABSTRACT: Huntington's disease is a neurodegenerative disorder involving psychiatric, cognitive and motor symptoms. Huntington's disease is caused by a tandem-repeat expansion in the huntingtin gene, which is widely expressed throughout the brain and body, including the gastrointestinal system. There are currently no effective disease-modifying treatments available for this fatal disorder. Despite recent evidence of gut microbiome disruption in preclinical and clinical Huntington's disease, its potential as a target for therapeutic interventions has not been explored. The microbiota-gut-brain axis provides a potential pathway through which changes in the gut could modulate brain function, including cognition. We now show that faecal microbiota transplant (FMT) from wild-type into Huntington's diseas

SUBMITTER: Gubert C 

PROVIDER: S-EPMC9400176 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature