A developmental role for the chromatin-regulating CoREST complex in the cnidarian Nematostella vectensis.

ABSTRACT:

Background

Chromatin-modifying proteins are key players in the regulation of development and cell differentiation in animals. Most chromatin modifiers, however, predate the evolution of animal multicellularity, and how they gained new functions and became integrated into the regulatory networks underlying development is unclear. One way this may occur is the evolution of new scaffolding proteins that integrate multiple chromatin regulators into larger complexes that facilitate coordinated deposition or removal of different chromatin modifications. We test this hypothesis by analyzing the evolution of the CoREST-Lsd1-HDAC complex.

Results

Using phylogenetic analyses, we show that a bona fide CoREST homolog is found only in choanoflagellates and animals. We then use the sea an

SUBMITTER: Gahan JM 

PROVIDER: S-EPMC9400249 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature