Location-specific signatures of Crohn's disease at a multi-omics scale.

ABSTRACT:

Background

Crohn's disease (CD), an inflammatory bowel disease (IBD) subtype, results from pathologic interactions between host cells and its resident gut microbes. CD manifests in both isolated disease locations (ileum or colon) or a combination of locations (ileocolonic). To date, a comprehensive understanding of how isolated CD subtypes influence molecular profiles remains outstanding. To address this, we sought to define CD location signatures by leveraging a large cross-sectional feature set captured from the stool of over 200 IBD patients and healthy controls using metaproteomics, shotgun metagenomics, 16S rRNA sequencing, metabolomic profiling, and host genetics paired with clinical endoscopic assessments.

Results

Neither metagenomic nor host genetics alone distinguis

SUBMITTER: Gonzalez CG 

PROVIDER: S-EPMC9400277 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature