Screening of primary open-angle glaucoma diagnostic markers based on immune-related genes and immune infiltration.

ABSTRACT:

Purpose

Primary open-angle glaucoma (POAG) continues to be a poorly understood disease. Although there were multiple researches on the identification of POAG biomarkers, few studies systematically revealed the immune-related cells and immune infiltration of POAG. Bioinformatics analyses of optic nerve (ON) and trabecular meshwork (TM) gene expression data were performed to further elucidate the immune-related genes of POAG and identify candidate target genes for treatment.

Methods

We performed a gene analysis of publicly available microarray data, namely, the GSE27276-GPL2507, GSE2378-GPL8300, GSE9944-GPL8300, and GSE9944-GPL571 datasets from the Gene Expression Omnibus database. The obtained datasets were used as input for parallel pathway analyses. Based on random forest a

SUBMITTER: Suo L 

PROVIDER: S-EPMC9400315 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature