Electrophilic Reagents for the Direct Incorporation of Uncommon SCF₂CF₂H and SCF₂CF₃ Motifs.

ABSTRACT: The introduction of fluoroalkylthioether groups has attracted the attention of the drug-discovery community given the special physicochemical and pharmacokinetic features they confer to bioactive compounds, yet these are often limited to standard SCF₃ and SCF₂H moieties. Herein, two saccharin-based electrophilic reagents have been disclosed for the incorporation of uncommon SCF₂CF₂H and SCF₂CF₃ motifs. Their reactivity performance, multigram-scale preparation, and divergent derivatization have been thoroughly investigated with a variety of nucleophiles, including natural products and pharmaceuticals.

SUBMITTER: Mestre J 

PROVIDER: S-EPMC9400389 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature