Radiation therapy for melanoma brain metastases: a systematic review.

ABSTRACT:

Background

Radiation therapy (RT) for melanoma brain metastases, delivered either as whole brain radiation therapy (WBRT) or as stereotactic radiosurgery (SRS), is an established component of treatment for this condition. However, evidence allowing comparison of the outcomes, advantages and disadvantages of the two RT modalities is scant, with very few randomised controlled trials having been conducted. This has led to considerable uncertainty and inconsistent guideline recommendations. The present systematic review identified 112 studies reporting outcomes for patients with melanoma brain metastases treated with RT. Three were randomised controlled trials but only one was of sufficient size to be considered informative. Most of the evidence was from non-randomised studies, either

SUBMITTER: Thompson JF 

PROVIDER: S-EPMC9400437 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature