Assessing strategies to target screening for advanced liver fibrosis among overweight and obese patients.

ABSTRACT:

Aim

The optimal screening strategy for advanced liver fibrosis in overweight and obese patients is unknown. The aim of this study is to compare the performance of different strategies to select patients at high risk of advanced liver fibrosis for screening using non-invasive tools.

Methods

All patients underwent: liver ¹H-MRS and percutaneous liver biopsy (in those with nonalcoholic fatty liver disease [NAFLD]). Unique selection strategies were compared to determine the best screening algorithm: (A) A "metabolic approach": selecting patients based on HOMA-IR ≥ 3; (B) A "diabetes approach": selecting only patients with type 2 diabetes; (C) An "imaging approach": selecting patients with hepatic steatosis based on ¹H-MRS; (D) A "liver biochemistry approach

SUBMITTER: Bril F 

PROVIDER: S-EPMC9400455 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature